Surface Functionalization of Upconversion Nanoparticle for Biological Usage

Devi Wahyuningtyas, Hsien-Ming Lee, Hua-De Gao

Abstract


Upconversion nanoparticle (UCNP) coated with uniform silica shells, which were further functionalized with poly(ethylene glycol) (PEG) and (3-aminopropyl)triethoxysilane (APTES), produces water dispersible core-shell structured UCNPs with average hydrodynamic size around 100 nm. The hydrothermal treatment to the particle stabilize amines of APTES on the surface of UCNPs. The stable and positive zeta potential also prove that the amines is successfully attached on the particle’s surface, with good stability in colloidal solution. We also discovered that hydrothermal treatment temperature over 200 oC diminish the luminescence properties of UCNPs.

Keywords


Upconversion, functionalization, silica, core-shell

Full Text:

PDF

References


X. Xue et al. “Emerging functional nanomaterials for therapeutics,” Journal of Materials Chemistry, vol. 21, no. 35, pp.13107-13127, 2011.

R. He et al. “Advances of upconversion nanoparticles for molecular imaging,” Nano Biomedicine and Engineering, vol. 5, no. 3, pp. 131-139, 2013.

J. Shen et al. “Lantanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy," Advanced Drug Delivery Review, vol. 65, no. 5, pp. 744-755, 2013.

G. Yi et al. “Synthesis, characterization, and biological application of size-controlled nanocrystalline NaYF4:Yb,Er infrared-to-visible up-conversion phosphors,” Nano Letters, vol. 4, no. 11, pp. 2191-2196, 2004.

Z. Li and Y. Zhang, “An efficient and user-friendly method for the synthesis of hexagonal-phase NaYF4:Yb, Er/Tm nanocrystals with controllable shape and upconversion fluorescence,” Nanotechnology, vol. 19, no. 34, pp. 345606-345610, 2008.

C. Liu and D. Chen, “Controlled synthesis of hexagon shaped lanthanide-doped LaF3 nanoplates with multicolor upconversion fluorescence,” Journal of Materials Chemistry, vol. 17, no. 37, pp. 3875-3880, 2007.

J. C. Boyer et al. “Synthesis of Colloidal Upconverting NaYF4 Nanocrystals Doped with Er3+, Yb3+ and Tm3+, Yb3+ via Thermal Decomposition of Lanthanide Trifluoroacetate Precursors,” Journal of American Chemical Society, vol. 128, no. 23, pp. 7444-7445, 2006.

L. D. Sun et al. “Paradigms and Challenges for Bioapplication of Rare Earth Upconversion Luminescent Nanoparticles: Small Size and Tunable Emission/Excitation Spectra,” Accounts of Chemical Research, vol. 47, no. 4, pp. 1001-1009, 2014.

R. A. Jalil and Y. Zhang, “Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals,” Biomaterials, vol. 29, no. 30, pp. 4122-4128, 2008.

C. Li et al. “A facile fabrication of upconversion luminescent and mesoporous core–shell structured β-NaYF4:Yb3+, Er3+@mSiO2 nanocomposite spheres for anti-cancer drug delivery and cell imaging,” Biomaterials Science, vol. 1, no. 2, pp. 213-223, 2013.




DOI: http://dx.doi.org/10.12962/j23546026.y2015i1.1181

Refbacks

  • There are currently no refbacks.


View my Stat: Click Here

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.