Sonication-Assisted Mitsunobu Etherification of Sterically Encumbered and Intramolecular Hydrogen Demanding Compounds: A Model towards Intramolecular MPV Reduction

Reinner I Lerrick

Abstract


A steric and intramolecular hydrogen bonding controlled substrates has been successfully etherified towards sonication assisted Mitsunobu reaction. This modified alcohol-alcohol coupling reaction of 2-hydroxyacetophenone, substituted 2-hydroxyecetophenone, benzophenone and substituted benzophenones with (2R,4R)-pentanediol was found to be substrate electronic restraint

Keywords


Mitsunobu Etherification; Sonication; phenoxyketones

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DOI: http://dx.doi.org/10.12962/j23546026.y2017i4.3065

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