Tinjauan Molekular Proses Loading dan Unloading Rifampicin pada Etil Selulosa dan (Etil selulosa)-g-(Poly-Dimethylaminoethyl Acrylate)

Mia Ledyastuti, Rachmawati Rachmawati, Ikhsan Ibrahim


Tuberkulosis merupakan penyakit menular dengan jumlah kematian 34 orang per 100.000 penduduk. Oleh karena itu,penelitian mengenai pengobatan tuberkulosis menjadi penting dari segi penghantaran obat maupun efektivitas obat. Kopolimer etil selulosa-g-(poly-dimethylaminoethylacrylate) atau EC-g-PDMAEA mempunyai potensi sebagai pembawa obat karena  dapat membentuk misel yang sesuai untuk jenis obat hidrofobik yaitu rifampicin. Pemahaman perilaku molekular dan interaksi EC-g-PDMAEA terhadap rifampicin menjadi bagian yang penting dalam sintesis dan aplikasi kopolimer dari etil selulosa ke depannya. Berdasarkan simulasi dinamika molekul menggunakan GROMACS 2020.6, EC-g-PDMAEA menghasilkan pola loading rifampicin yang mirip dengan pola loading dari etil selulosa (EC). Pola unloading dari EC-g-PDMAEA menunjukkan tren data yang lebih baik dibandingkan dengan EC dari segi pergeseran puncak Radial Distribution Function yang diamati untuk rifampicin dari jarak 0,86 menuju 0,96 nm. 


rifampicin; dinamika molekul; misel; penghantaran obat

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DOI: http://dx.doi.org/10.12962/j25493736.v8i1.16517


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